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Drosophila melanogaster has well-characterized genetics that is amenable to manipulation. A cluster of cells in ovaries, the border cell, migrates collectively during development. Border cell clusters are useful in understanding collective cell migration in vivo and important in the study of development and disease progression. Cytokine and steroid hormone signaling pathways are important for the regulation of border cell migration. Based on previous data, we hypothesized that the ferritin complex, a target of steroid hormone signaling, modulates migration. Ferritin is an iron storage complex made of heavy and light chains. Preliminary results indicate that lowering ferritin gene expression results in defective migration. We are characterizing the spatiotemporal expression of ferritin genes. Additionally, we are mining genomic data for transcription factor binding sites that regulate ferritin expression.Racial Identity Synthesis Video
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